3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype

J Med Chem. 1997 Oct 24;40(22):3497-500. doi: 10.1021/jm9704558.

Authors

J L Castro¹, L J Street, A R Guiblin, R A Jelley, M G Russell, F Sternfeld, M S Beer, J A Stanton, V G Matassa

Affiliation

¹ Chemistry Department, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, U.K.

PMID: 9357514
DOI: 10.1021/jm9704558

No abstract available

MeSH terms

Humans
Piperidines / chemistry
Piperidines / metabolism
Piperidines / pharmacology*
Protein Binding
Pyrrolidines / chemistry
Pyrrolidines / metabolism
Pyrrolidines / pharmacology*
Receptor, Serotonin, 5-HT1B
Receptor, Serotonin, 5-HT1D
Receptors, Serotonin / drug effects*
Receptors, Serotonin / metabolism
Recombinant Proteins / drug effects
Serotonin Receptor Agonists / chemistry
Serotonin Receptor Agonists / metabolism
Serotonin Receptor Agonists / pharmacology*

Substances

HTR1B protein, human
Piperidines
Pyrrolidines
Receptor, Serotonin, 5-HT1B
Receptor, Serotonin, 5-HT1D
Receptors, Serotonin
Recombinant Proteins
Serotonin Receptor Agonists